トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル/(CAPRYLIC/CAPRIC/MYRISTIC/STEARIC

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルとは

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルは、カプリル酸、カプリン酸、ミリスチン酸及びステアリン酸からなる混合脂肪酸とグリセリン（＊）のトリエステルです(1)。

INCI名は、Caprylic/Capric/Myristic/Stearic Triglycerideです。

また、医薬部外品原料規格では、「トリ（カプリル・カプリン・ミリスチン・ステアリン酸）グリセリル」、英名 Tri(Caprylic/Capric/Myristic/Stearic) Glyceryl」として収載され、カプリル酸約 25%、「カプリン酸」約 15%、「ミリスチン酸」約 20%、及び「ステアリン酸」約 40%の混合脂肪酸と、グリセリンからなるトリグリセリドで、けん化価： 240～265と規定されています。

肌上で溶ける伸びの良い固形油で、保湿性に優れた油剤で、全て植物由来原料を使用しています(3)。

ラードに似た組成をもちながら、優れた酸化安定性を持ち均一性のある、べたつかず滑らかな感触が特長です(4)。

低極性エステル、高極性エステル、植物油、ひまし油、流動パラフィンに可溶で、水に不溶な物質です。

化粧品分野では、クリーム、乳液、口紅、ファンデーション、ヘアトリートメント、マスカラ、クレンジングクリーム、ペンシル類に使用されています(3)。

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルの配合目的

展延性

酸化安定性

感触改良

https://www.cir-safety.org/sites/default/files/trygly122017FAR.pdf

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルの安全性情報

https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR742.pdf

参考文献

(1) 化粧品の成分表示名称リスト　トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル

(2) 医薬部外品原料規格　トリ（カプリル・カプリン・ミリスチン・ステアリン酸）グリセリル

(3) サラコス３３４　日清オイリオグループ株式会社　日清オイリオグループの化粧品原料製品カタログ

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルに関する日本語の参考論文

炭素鎖の異なる脂肪酸塩による小麦粉パンの生地改良効果

濱石貴士 , 森永賀亮 , 森田洋　日本調理科学会大会研究発表要旨集 29(0), 81, 2017

犬の膿皮症由来 Staphylococcus sp および外耳炎由来 Malassezia sp に対する脂肪酸の抗菌効果

小泉亜希子 , 西尾裕将 , 池田理沙 , 植田李美 , 関口麻衣子 , 大辻一也　ベテリナリー・ナーシング 20(2), 17-20, 2015

灰色かび病菌(Botrytis cinerea PEAS.)に対するショ糖脂肪酸エステル, グリセリンおよびポリグリセリン脂肪酸エステルの抗菌効果について

辰巳保夫 , 羽立智美 , 松尾聡子 [他] , 津野和宣　日本食品保蔵科学会誌 = Food preservation science 28(5), 227-234, 2002-09-30

臭化セシウム領域における直鎖脂肪酸の赤外線吸収スペクトル

河野通郎　日本化學雜誌 81(11), 1652-1655, 1960

トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリルに関する英語の参考論文

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The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems.

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Re-evaluation of fatty acids (E 570) as a food additive.

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Comparison of the structures of triacylglycerols from native and transgenic medium-chain fatty acid-enriched rape seed oil by liquid chromatography--atmospheric pressure chemical ionization ion-trap mass spectrometry (LC-APCI-ITMS).

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Determination of free fatty acids in beer.

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Susceptibility of Clostridium perfringens to C-C fatty acids.

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Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography.

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Dietary fat saturation effects on low-density-lipoprotein concentrations and metabolism in various animal models.

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Antioxidant properties of tyrosol and hydroxytyrosol saturated fatty acid esters.

Sun Y, Zhou D, Shahidi F.Food Chem. 2018 Apr 15;245:1262-1268. doi: 10.1016/j.foodchem.2017.11.051. Epub 2017 Nov 14.PMID: 29287352 No abstract available.

The effect of six different C18 fatty acids on body fat and energy metabolism in mice.

Javadi M, Everts H, Hovenier R, Kocsis S, Lankhorst AE, Lemmens AG, Schonewille JT, Terpstra AH, Beynen AC.Br J Nutr. 2004 Sep;92(3):391-9. doi: 10.1079/bjn20041217.PMID: 15469642

Quantifying protein-fatty acid interactions using electrospray ionization mass spectrometry.

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Optimization of enzymatic hydrolysis of cellulosic fraction obtained from stranded driftwood feedstocks for lipid production by Solicoccozyma terricola.

Tasselli G, Filippucci S, D'Antonio S, Cavalaglio G, Turchetti B, Cotana F, Buzzini P.Biotechnol Rep (Amst). 2019 Aug 7;24:e00367. doi: 10.1016/j.btre.2019.e00367. eCollection 2019 Dec.PMID: 31453116 Free PMC article.

Analysis of free fatty acids in beer: comparison of solid-phase extraction, solid-phase microextraction, and stir bar sorptive extraction.

Horák T, Culík J, Cejka P, Jurková M, Kellner V, Dvorák J, Hasková D.J Agric Food Chem. 2009 Dec 9;57(23):11081-5. doi: 10.1021/jf9028305.PMID: 19904941

[Interaction of free fatty acids with mitochondria during uncoupling of oxidative phosphorylation].

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The solid-liquid phase diagrams of binary mixtures of consecutive, even saturated fatty acids.

Costa MC, Sardo M, Rolemberg MP, Coutinho JA, Meirelles AJ, Ribeiro-Claro P, Krähenbühl MA.Chem Phys Lipids. 2009 Aug;160(2):85-97. doi: 10.1016/j.chemphyslip.2009.05.004. Epub 2009 Jun 9.PMID: 19520067 Free article.

Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae).

Urbanek A, Szadziewski R, Stepnowski P, Boros-Majewska J, Gabriel I, Dawgul M, Kamysz W, Sosnowska D, Gołębiowski M.J Insect Physiol. 2012 Sep;58(9):1265-76. doi: 10.1016/j.jinsphys.2012.06.014. Epub 2012 Jul 7.PMID: 22781366

Binding free energy calculations between bovine β-lactoglobulin and four fatty acids using the MMGBSA method.

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Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: a new hypothesis for the mechanism of action of fish oil in rheumatic diseases.

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Specific long-chain fatty acids promote optimal growth of Frankia: accumulation and intracellular distribution of palmitic and propionic acid.

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High-pressure liquid chromatography of fatty acid esters of retinol isomers. Analysis of retinyl esters stored in the eye.

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Kinetics of drug binding to human serum albumin: allosteric and competitive inhibition at the benzodiazepine binding site by free fatty acids of various chain lengths.

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