トリ(カプリル酸/カプリン酸)グリセリル|化粧品全成分|INGREBANK

トリ(カプリル酸/カプリン酸)グリセリルとは

カプリル酸及びカプリン酸とグリセリンのトリエステルの混合物です。

医薬部外品原料規格では「トリ（カプリル・カプリン酸）グリセリル」英名Caprylic/Capric Acid Triglycerideとして収載され、けん化価 330～360と規定されています(1)。

また、同じ製品が、医薬品添加物規格、109201「中鎖脂肪酸トリグリセリド」としても扱われることもあります(2)。INCI名は、 CAPRYLIC/CAPRIC TRIGLYCERIDEです。

植物系の脂肪酸と植物系のアルコールを反応させた物質で、極めて生体への安全性が高い中鎖脂肪酸トリグリセライドです。酸化しにくく、なめらかな軽い使用感が特長の液状の物質です。

化粧品分野では、なめらかな使用感とべたつかない軽い感触を与えることから、日焼け止め、ボディクリーム、美容液、口紅、クレンジング、アイシャドウ、ブレストパウダー、ハンドクリーム、シャンプー、リンス、ヘアパックなどに用いられています。

危険物分類では、第 4 類: 引火性液体, 動植物油類, 非水溶性液体, 指定数量 (10000 リットル)危険等級 IIIに分類される物質です。GHS分類では該当せず、有害性は報告されていません(4)。

化粧品での用途

エタノール、シクロペンタシロキサン、ジメチコン(10 mm²/s)、オリーブ油、流動パラフィンに溶解します。

適用範囲は、クリームや軟膏の油性基剤、油溶性ビタミン類の溶剤や賦型剤、座薬の硬度調整剤などの香粧品、医薬品原料、食用油脂、食用離型油美容液と幅広く、数多くの製品があります(4)

トリ(カプリル酸/カプリン酸)グリセリルの配合目的

保湿剤

感触改良剤

トリ(カプリル酸/カプリン酸)グリセリルの安全性情報

https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR742.pdf

参考文献

(1) 医薬品添加物規格　トリ(カプリル・カプリン酸）グリセリル

(4)ココナードＭＴ　安全データシート

トリ(カプリル酸/カプリン酸)グリセリルに関する日本語の参考論文

カルボキシデシルトリシロキサンを含むα型水和結晶相の発見とその物理化学的特性

宇山允人　色材協会誌 93(3), 70-72, 2020

粉体用分散剤としてのポリグリセリン肪脂酸エステル　界面張力測定による分散剤の評価:界面張力測定による分散剤の評価

中村順一 , 高橋和彦 , 村田友次　日本化粧品技術者会誌 31(3), 297-303, 1997

トリ(カプリル酸/カプリン酸)グリセリルに関する英語の参考論文

Allergic contact dermatitis caused by caprylic/capric triglyceride from an anti-aging cosmetic cream.

Navarro-Triviño FJ, Ruiz-Villaverde R.Contact Dermatitis. 2020 Dec;83(6):508-510. doi: 10.1111/cod.13641. Epub 2020 Jul 13.PMID: 32542693 No abstract available.

A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.

Khmaladze I, Österlund C, Smiljanic S, Hrapovic N, Lafon-Kolb V, Amini N, Xi L, Fabre S.J Cosmet Dermatol. 2020 Jun;19(6):1415-1425. doi: 10.1111/jocd.13176. Epub 2019 Oct 4.PMID: 31584241

Lipid nanostructures for antioxidant delivery: a comparative preformulation study.

Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Valacchi G, Cortesi R.Beilstein J Nanotechnol. 2019 Aug 29;10:1789-1801. doi: 10.3762/bjnano.10.174. eCollection 2019.PMID: 31501750 Free PMC article.

Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-methoxycinnamate.

do Prado AH, Araújo VHS, Eloy JO, Fonseca-Santos B, Pereira-da-Silva MA, Peccinini RG, Chorilli M.AAPS PharmSciTech. 2020 Apr 29;21(4):125. doi: 10.1208/s12249-019-1547-0.PMID: 32350635

Progesterone lipid nanoparticles: Scaling up and in vivo human study.

Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Cortesi R.Eur J Pharm Biopharm. 2017 Oct;119:437-446. doi: 10.1016/j.ejpb.2017.07.015. Epub 2017 Jul 29.PMID: 28760448

**Skin** moisturization by hydrogenated polyisobutene--quantitative and visual evaluation.

Dayan N, Sivalenka R, Chase J.J Cosmet Sci. 2009 Jan-Feb;60(1):15-24.PMID: 19296892

Preformulation and characterization of raloxifene-loaded lipid nanoparticles for transdermal administration.

Alves GL, Teixeira FV, da Rocha PBR, Krawczyk-Santos AP, Andrade LM, Cunha-Filho M, Marreto RN, Taveira SF.Drug Deliv Transl Res. 2021 Mar 7. doi: 10.1007/s13346-021-00949-y. Online ahead of print.PMID: 33682031

Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism-blocking agent.

Baert B, De Spiegeleer B.Skin Pharmacol Physiol. 2011;24(3):151-9. doi: 10.1159/000323012. Epub 2011 Jan 12.PMID: 21228620

Review of the toxicologic properties of medium-chain triglycerides.

Traul KA, Driedger A, Ingle DL, Nakhasi D.Food Chem Toxicol. 2000 Jan;38(1):79-98. doi: 10.1016/s0278-6915(99)00106-4.PMID: 10685018 Review.

Dermal Delivery of Niacinamide-In Vivo Studies.

Zhang Y, Kung CP, Iliopoulos F, Sil BC, Hadgraft J, Lane ME.Pharmaceutics. 2021 May 14;13(5):726. doi: 10.3390/pharmaceutics13050726.PMID: 34069268 Free PMC article.

Method for quantification of oils and sebum levels on skin using the Sebumeter().

Crowther JM.Int J Cosmet Sci. 2016 Apr;38(2):210-6. doi: 10.1111/ics.12258. Epub 2015 Jul 27.PMID: 26114451

Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment.

Leite-Silva VR, Sanchez WY, Studier H, Liu DC, Mohammed YH, Holmes AM, Ryan EM, Haridass IN, Chandrasekaran NC, Becker W, Grice JE, Benson HA, Roberts MS.Eur J Pharm Biopharm. 2016 Jul;104:140-7. doi: 10.1016/j.ejpb.2016.04.022. Epub 2016 Apr 27.PMID: 27131753

Data on scaling up and in vivo human study of progesterone lipid nanoparticles.

Esposito E, Sguizzato M, Drechsler M, Mariani P, Carducci F, Nastruzzi C, Cortesi R.Data Brief. 2017 Aug 31;14:639-642. doi: 10.1016/j.dib.2017.08.033. eCollection 2017 Oct.PMID: 28913392 Free PMC article.

Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models.

Drewes CC, Fiel LA, Bexiga CG, Asbahr AC, Uchiyama MK, Cogliati B, Araki K, Guterres SS, Pohlmann AR, Farsky SP.Int J Nanomedicine. 2016 Mar 31;11:1261-79. doi: 10.2147/IJN.S101543. eCollection 2016.PMID: 27099491 Free PMC article.

Mechanism study on ion-pair complexes controlling skin permeability: Effect of ion-pair dissociation in the viable epidermis on transdermal permeation of bisoprolol.

Zhao H, Liu C, Quan P, Wan X, Shen M, Fang L.Int J Pharm. 2017 Oct 30;532(1):29-36. doi: 10.1016/j.ijpharm.2017.08.080. Epub 2017 Aug 19.PMID: 28830782

Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances.

Savić V, Todosijević M, Ilić T, Lukić M, Mitsou E, Papadimitriou V, Avramiotis S, Marković B, Cekić N, Savić S.Int J Pharm. 2017 Aug 30;529(1-2):491-505. doi: 10.1016/j.ijpharm.2017.07.036. Epub 2017 Jul 12.PMID: 28711641

Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules.

Zhou H, Yue Y, Liu G, Li Y, Zhang J, Yan Z, Duan M.Nanoscale Res Lett. 2010 Jul 20;5(10):1561-9. doi: 10.1007/s11671-010-9677-z.PMID: 21076708 Free PMC article.

An in vivo confocal Raman study of the delivery of trans retinol to the skin.

Pudney PD, Mélot M, Caspers PJ, Van Der Pol A, Puppels GJ.Appl Spectrosc. 2007 Aug;61(8):804-11. doi: 10.1366/000370207781540042.PMID: 17716398

Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing.

Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G.Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.PMID: 29779480

Microemulsion for topical application of pentoxifylline: In vitro release and in vivo evaluation.

Cavalcanti AL, Reis MY, Silva GC, Ramalho ÍM, Guimarães GP, Silva JA, Saraiva KL, Damasceno BP.Int J Pharm. 2016 Jun 15;506(1-2):351-60. doi: 10.1016/j.ijpharm.2016.04.065. Epub 2016 Apr 27.PMID: 27130362

Topical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity.

Lopes LB, VanDeWall H, Li HT, Venugopal V, Li HK, Naydin S, Hosmer J, Levendusky M, Zheng H, Bentley MV, Levin R, Hass MA.J Pharm Sci. 2010 Mar;99(3):1346-57. doi: 10.1002/jps.21929.PMID: 19798758

Influence of the emollient on emulsions containing lamellar liquid crystals: from molecular organization towards applicative properties.

Terescenco D, Savary G, Picard C, Clemenceau F, Merat E, Grisel M.Int J Cosmet Sci. 2018 Dec;40(6):565-574. doi: 10.1111/ics.12498. Epub 2018 Nov 29.PMID: 30303546

An attempt to clarify the mechanism of the penetration enhancing effects of lipophilic vehicles with differential scanning calorimetry (DSC).

Leopold CS, Lippold BC.J Pharm Pharmacol. 1995 Apr;47(4):276-81. doi: 10.1111/j.2042-7158.1995.tb05795.x.PMID: 7791023

Vibrational spectroscopy coupled to classical least square analysis, a new approach for determination of skin moisturizing agents' mechanisms.

Vyumvuhore R, Tfayli A, Manfait M, Baillet-Guffroy A.Skin Res Technol. 2014 Aug;20(3):282-92. doi: 10.1111/srt.12117. Epub 2013 Nov 21.PMID: 24256135

Relative Penetration of Zinc Oxide and Zinc Ions into Human Skin after Application of Different Zinc Oxide Formulations.

Holmes AM, Song Z, Moghimi HR, Roberts MS.ACS Nano. 2016 Feb 23;10(2):1810-9. doi: 10.1021/acsnano.5b04148. Epub 2016 Jan 21.PMID: 26741484

Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy.

Mélot M, Pudney PD, Williamson AM, Caspers PJ, Van Der Pol A, Puppels GJ.J Control Release. 2009 Aug 19;138(1):32-9. doi: 10.1016/j.jconrel.2009.04.023. Epub 2009 May 4.PMID: 19401210

The effect of dimethylsulfoxide, 1-[2-(decylthio)ethyl]azacyclopentan-2-one and Labrafac()CC on porphyrin formation in normal mouse skin during topical application of methyl 5-aminolevulinate: A fluorescence and extraction study.

Bugaj A, Iani V, Juzeniene A, Juzenas P, Ma LW, Moan J.Photodiagnosis Photodyn Ther. 2006 Mar;3(1):27-33. doi: 10.1016/S1572-1000(05)00109-2. Epub 2006 Jan 20.PMID: 25049025

Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives.

Kim JH, Lee CH, Choi HK.Drug Dev Ind Pharm. 2002 Aug;28(7):833-9. doi: 10.1081/ddc-120005629.PMID: 12236069

Studies of in vitro skin permeation and retention of a leukotriene antagonist from topical vehicles with a hairless guinea pig model.

Kumar S, Malick AW, Meltzer NM, Mouskountakis JD, Behl CR.J Pharm Sci. 1992 Jul;81(7):631-4. doi: 10.1002/jps.2600810708.PMID: 1403694

Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats.

Magalhães MS, Fechine FV, Macedo RN, Monteiro DL, Oliveira CC, Brito GA, Moraes ME, Moraes MO.Acta Cir Bras. 2008 May-Jun;23(3):262-9. doi: 10.1590/s0102-86502008000300009.PMID: 18552998

Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo.

Leopold CS, Lippold BC.J Pharm Sci. 1995 Feb;84(2):195-8. doi: 10.1002/jps.2600840214.PMID: 7738800 Clinical Trial.

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