ツボクサエキスの配合目的

これらの目的で、スキンケア化粧品、ボディケア製品、クレンジング製品、洗顔料、リップケア製品、メイクアップ化粧品、シート&マスク製品などに使用されています。

ツボクサエキスの安全性情報

https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR685.pdf

ツボクサエキスの日本語の参考論文

ハーブの食品素材活用術 : 食経験から機能性を探る(第62回)ゴツコラ : アーユルヴェーダの若返りハーブは脳を活性する

橋口 智親

Food style 21 : 食品の機能と健康を考える科学情報誌 25(2), 20-25, 2021-02

低分子ヒアルロン酸の美肌効果--ゴツコラエキスとの併用 (特集 肌の健康と美肌)

内本 啓史 , 新堀 祐

Food style 21 12(2), 40-43, 2008-02

機能性研究レポート ゴツコラエキスと美容

大野 弘美 , 新堀 祐 Food style 21 11(5), 77-80, 2007-05

ツボクサエキスの英語の参考論文

**Centella** asiatica in dermatology: an overview.

Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M.Phytother Res. 2014 Aug;28(8):1117-24. doi: 10.1002/ptr.5110. Epub 2014 Jan 7.PMID: 24399761 Review.

Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract.

Ratz-Łyko A, Arct J, Pytkowska K.Indian J Pharm Sci. 2016 Jan-Feb;78(1):27-33. doi: 10.4103/0250-474x.180247.PMID: 27168678 Free PMC article.

Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.

Lee Y, Choi HK, N'deh KPU, Choi YJ, Fan M, Kim EK, Chung KH, An AJH.Nutrients. 2020 Feb 5;12(2):411. doi: 10.3390/nu12020411.PMID: 32033291 Free PMC article.

Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits.

Sh Ahmed A, Taher M, Mandal UK, Jaffri JM, Susanti D, Mahmood S, Zakaria ZA.BMC Complement Altern Med. 2019 Aug 14;19(1):213. doi: 10.1186/s12906-019-2625-2.PMID: 31412845 Free PMC article.

The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial.

Damkerngsuntorn W, Rerknimitr P, Panchaprateep R, Tangkijngamvong N, Kumtornrut C, Kerr SJ, Asawanonda P, Tantisira MH, Khemawoot P.J Altern Complement Med. 2020 Jun;26(6):529-536. doi: 10.1089/acm.2019.0325. Epub 2020 Apr 20.PMID: 32310680 Clinical Trial.

Dermal targeting of Centella asiatica extract using hyaluronic acid surface modified niosomes.

Wichayapreechar P, Anuchapreeda S, Phongpradist R, Rungseevijitprapa W, Ampasavate C.J Liposome Res. 2020 Jun;30(2):197-207. doi: 10.1080/08982104.2019.1614952. Epub 2019 May 27.PMID: 31060402

Development of a High-Performance Liquid Chromatographic Method for Asiaticoside Quantification in Different Skin Layers after Topical Application of a Centella asiatica Extract.

da Rocha PBR, Souza BDS, Andrade LM, Marreto RN, Lima EM, Taveira SF.Planta Med. 2017 Dec;83(18):1431-1437. doi: 10.1055/s-0043-113325. Epub 2017 Jun 26.PMID: 28651288

Aqueous extract of Centella asiatica promotes corneal epithelium wound healing in vitro.

Ruszymah BH, Chowdhury SR, Manan NA, Fong OS, Adenan MI, Saim AB.J Ethnopharmacol. 2012 Mar 27;140(2):333-8. doi: 10.1016/j.jep.2012.01.023. Epub 2012 Jan 24.PMID: 22301444

The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study.

Milani M, Sparavigna A.Clin Cosmet Investig Dermatol. 2017 Aug 11;10:311-315. doi: 10.2147/CCID.S144180. eCollection 2017.PMID: 28860834 Free PMC article.

Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica.

Nema NK, Maity N, Sarkar BK, Mukherjee PK.Pharm Biol. 2013 Sep;51(9):1182-7. doi: 10.3109/13880209.2013.782505. Epub 2013 Jun 13.PMID: 23763301

Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model.

Yao CH, Yeh JY, Chen YS, Li MH, Huang CH.J Tissue Eng Regen Med. 2017 Mar;11(3):905-915. doi: 10.1002/term.1992. Epub 2015 Feb 25.PMID: 25711743

TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper.

Belcaro G, Maquart FX, Scoccianti M, Dugall M, Hosoi M, Cesarone MR, Luzzi R, Cornelli U, Ledda A, Feragalli B.Panminerva Med. 2011 Sep;53(3 Suppl 1):105-18.PMID: 22108486 Review.

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model.

Park JH, Choi JY, Son DJ, Park EK, Song MJ, Hellström M, Hong JT.Int J Mol Sci. 2017 Mar 30;18(4):738. doi: 10.3390/ijms18040738.PMID: 28358324 Free PMC article.

Evaluation of the topical spray containing Centella asiatica extract and its efficacy on excision wounds in rats.

Sawatdee S, Choochuay K, Chanthorn W, Srichana T.Acta Pharm. 2016 Jun 1;66(2):233-44. doi: 10.1515/acph-2016-0018.PMID: 27279066

**Centella** asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts.

Kim YJ, Cha HJ, Nam KH, Yoon Y, Lee H, An S.Exp Dermatol. 2011 Dec;20(12):998-1003. doi: 10.1111/j.1600-0625.2011.01388.x.PMID: 22092576

Postpartum stretchmarks: repairing activity of an oral Centella asiatica supplementation (Centellicum).

Hu S, Belcaro G, Hosoi M, Feragalli B, Luzzi R, Dugall M.Minerva Ginecol. 2018 Oct;70(5):629-634. doi: 10.23736/S0026-4784.18.04254-5.PMID: 30293400

Effects of Centella asiatica extract on dermal wound healing in rats.

Suguna L, Sivakumar P, Chandrakasan G.Indian J Exp Biol. 1996 Dec;34(12):1208-11.PMID: 9246912

Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts.

An IS, An S, Kang SM, Choe TB, Lee SN, Jang HH, Bae S.Int J Mol Med. 2012 Nov;30(5):1194-202. doi: 10.3892/ijmm.2012.1117. Epub 2012 Sep 4.PMID: 22948173

Electrospun gelatin fiber mats containing a herbal-Centella asiatica-extract and release characteristic of asiaticoside.

Sikareepaisan P, Suksamrarn A, Supaphol P.Nanotechnology. 2008 Jan 9;19(1):015102. doi: 10.1088/0957-4484/19/01/015102. Epub 2007 Nov 29.PMID: 21730522

In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.

Sampson JH, Raman A, Karlsen G, Navsaria H, Leigh IM.Phytomedicine. 2001 May;8(3):230-5. doi: 10.1078/0944-7113-00032.PMID: 11417919

Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis.

Ju Ho P, Jun Sung J, Ki Cheon K, Jin Tae H.Phytomedicine. 2018 Apr 1;43:110-119. doi: 10.1016/j.phymed.2018.04.013. Epub 2018 Apr 6.PMID: 29747743

Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study.

Somboonwong J, Kankaisre M, Tantisira B, Tantisira MH.BMC Complement Altern Med. 2012 Jul 20;12:103. doi: 10.1186/1472-6882-12-103.PMID: 22817824 Free PMC article.

A beta-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores.

Lee MS, Seo SR, Kim JC.Clin Exp Dermatol. 2012 Oct;37(7):762-71. doi: 10.1111/j.1365-2230.2011.04331.x. Epub 2012 Mar 22.PMID: 22439751

In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19).

Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE.J Ethnopharmacol. 2011 Jan 27;133(2):881-7. doi: 10.1016/j.jep.2010.11.026. Epub 2010 Nov 18.PMID: 21093571

[Topical chemotherapy for the treatment of burns].

Salas Campos L, Fernándes Mansilla M, Martínez de la Chica AM.Rev Enferm. 2005 May;28(5):67-70.PMID: 15981974 Spanish.

**Centella** asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer.

Hausen BM.Contact Dermatitis. 1993 Oct;29(4):175-9. doi: 10.1111/j.1600-0536.1993.tb03532.x.PMID: 8281778

Creams for preventing stretch marks in pregnancy.

Young GL, Jewell D.Cochrane Database Syst Rev. 2000;(2):CD000066. doi: 10.1002/14651858.CD000066.PMID: 10796111 Updated. Review.

A Prospective Randomized, Controlled, Double-Blind Trial of the Efficacy Using Centella Cream for Scar Improvement.

Jenwitheesuk K, Rojsanga P, Chowchuen B, Surakunprapha P.Evid Based Complement Alternat Med. 2018 Sep 17;2018:9525624. doi: 10.1155/2018/9525624. eCollection 2018.PMID: 30310413 Free PMC

article.

Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model.

Lee JH, Kim HL, Lee MH, You KE, Kwon BJ, Seo HJ, Park JC.Phytomedicine. 2012 Oct 15;19(13):1223-7. doi: 10.1016/j.phymed.2012.08.002. Epub 2012 Aug 30.PMID: 22939261

[Asiaticoside; active constituent of Centella asiatica, initiating agent of the new growth in the early stage of cicatrization of skin ulcers].

THIERS H, FAYOLLE J, BOITEAU P, RATSIMAMANGA AR.Lyon Med. 1957 Apr 28;89(17):389-95.PMID: 13440135 French. No abstract available.

Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles.

Paolino D, Cosco D, Cilurzo F, Trapasso E, Morittu VM, Celia C, Fresta M.J Control Release. 2012 Aug 20;162(1):143-51. doi: 10.1016/j.jconrel.2012.05.050. Epub 2012 Jun 12.PMID: 22698941

Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism.

Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M.Eur J Pharmacol. 2008 Apr 28;584(2-3):415-23. doi: 10.1016/j.ejphar.2008.02.036. Epub 2008 Feb 21.PMID: 18353310